Colchicine bertindak dengan menghalang penghijrahan sel darah putih (neutrofil) ke kawasan yang terjejas. Ini ibarat menghentikan kemasukan pasukan bomba yang tidak diperlukan ke kawasan kebakaran kecil—keradangan akan berkurang, dan kesakitan beransur-ansur reda.
A combination of diet plan and lifestyle alterations and prescription medicine — an approach called urate (uric acid) -lowering therapy, or ULT — is typically encouraged if attacks recur or develop into additional severe.
Uric acid is built in the body from purines present in some foods. This uric acid (hyperuricemia) build-up triggers suffering and swelling, typically in one joint at a time. The large toe is commonly the 1st body portion which is afflicted.
Kortikosteroid, sama ada diambil secara oral (melalui mulut) atau diberikan sebagai suntikan ke dalam sendi terjejas
The ACR notes that sufferers are most inspired for therapy through an exacerbation. Anti-inflammatory medications for instance colchicine or nonsteroidal anti-inflammatory medicines (NSAIDs) ought to be continued for 3 to 6 months right after starting up urate-lowering therapy.
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Jenis ubat ini dapat memendekkan waktu serangan, terutama jika ia diambil dalam 24 jam pertama serangan. Oleh itu, ubat NSAID perlu diambil sebaik sahaja anda merasakan ada gejala.
Untuk memahami cara colchicine berfungsi, bayangkan ia seperti “pengawal trafik” yang menguruskan keradangan dalam badan.
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Selain itu, pisang juga membantu mengurangkan bengkak pada sendi sekali gus mengurangkan kesakitan yang anda rasai. Anda boleh makan 2 biji pisang setiap pagi dan malam untuk mendapat kebaikannya.
Walaupun dianggap lebih berkesan, ubat steroid juga boleh menyebabkan kesan sampingan, seperti perubahan mood dan peningkatan gula darah dan tekanan darah. Ubat steroid yang boleh disuntik boleh menyebabkan kerosakan pada ligamen dan tulang rawan jika terlalu kerap digunakan.
Colcrys (colchicine) is best when started off at the initial symptoms of a gout flare. Colchicine may well have to be dosed decreased for people with Serious kidney sickness (CKD) and people who acquire some prescription drugs, for example statins.